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[[Drug overdose|Overdose]] of paracetamol is caused by taking more than the recommended maximum daily dose of paracetamol for healthy adults (three or four grams),<ref name=UK2017/><ref name=Med2018/> and can cause potentially fatal [[Hepatotoxicity|liver damage]].<ref>{{cite web |title=Acetaminophen Information |website=U.S. [[Food and Drug Administration]] |date=14 November 2017 |url=https://www.fda.gov/drugs/information-drug-class/acetaminophen-information |archive-url= https://web.archive.org/web/20191028022254/https://www.fda.gov/drugs/information-drug-class/acetaminophen-information |archive-date=28 October 2019 |url-status=live |access-date=27 October 2019}}{{PD-notice}}</ref><ref>{{cite web |title=Using Acetaminophen and Nonsteroidal Anti-inflammatory Drugs Safely |website=U.S. [[Food and Drug Administration]] (FDA) |date=26 February 2018 |url=https://www.fda.gov/drugs/safe-use-over-counter-pain-relievers-and-fever-reducers/using-acetaminophen-and-nonsteroidal-anti-inflammatory-drugs-safely |archive-url=https://web.archive.org/web/20191028025936/https://www.fda.gov/drugs/safe-use-over-counter-pain-relievers-and-fever-reducers/using-acetaminophen-and-nonsteroidal-anti-inflammatory-drugs-safely |archive-date=28 October 2019 |url-status=live |access-date=27 October 2019}}{{PD-notice}}</ref> A single dose should not exceed 1000 mg, doses should be taken no sooner than four hours apart, and no more than four doses (4000 mg) in 24 hours.<ref name=UK2017/> While a majority of adult overdoses are linked to suicide attempts, many cases are accidental, often due to the use of more than one paracetamol-containing product over an extended period.<ref>{{cite journal | vauthors = Amar PJ, Schiff ER | title = Acetaminophen safety and hepatotoxicity--where do we go from here? | journal = Expert Opinion on Drug Safety | volume = 6 | issue = 4 | pages = 341–355 | date = July 2007 | pmid = 17688378 | doi = 10.1517/14740338.6.4.341 | s2cid = 20399748 }}</ref>
[[Paracetamol toxicity]] has become the foremost cause of [[acute liver failure]] in the [[United States]] by 2003,<ref name="Larson2005" /> and {{As of|2005|lc=y}}, paracetamol accounted for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand.<ref>{{cite journal | vauthors = Buckley N, Eddleston M | title = Paracetamol (acetaminophen) poisoning | journal = Clinical Evidence | issue = 14 | pages = 1738–1744 | date = December 2005 | pmid = 16620471 | url = https://pubmed.ncbi.nlm.nih.gov/16620471/ }}</ref>
Overdoses are frequently related to high-dose [[Recreational drug use|recreational use]] of prescription [[opioids]], as these opioids are most often combined with paracetamol.<ref>{{cite news |url=https://www.cnn.com/2014/01/15/health/fda-acetaminophen-dosage/index.html |vauthors=Yan H |title=FDA: Acetaminophen doses over 325 mg may lead to liver damage |publisher=[[CNN]] |access-date=18 February 2014 |date=16 January 2014 |url-status=live |archive-url= https://web.archive.org/web/20140216091112/http://www.cnn.com/2014/01/15/health/fda-acetaminophen-dosage/index.html?hpt=hp_t2 |archive-date=16 February 2014}}</ref> The overdose risk may be heightened by frequent consumption of alcohol.<ref name="Lee2017">{{cite journal |vauthors=Lee WM |title=Acetaminophen (APAP) hepatotoxicity—Isn't it time for APAP to go away? |journal=Journal of Hepatology |volume=67 |issue=6 |pages=1324–1331 |date=December 2017 |pmid=28734939 |pmc=5696016 |doi=10.1016/j.jhep.2017.07.005}}</ref>
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