SPR741: Difference between revisions

'''SPR741''' is an experimental [[antibiotic]] related to [[Polymyxin B]]. It shows activity against a number of bacterial pathogens, especially ''[[Acinetobacter baumannii]]'' and ''[[Klebsiella pneumoniae]]'', acting as an antibiotic [[adjuvant]] which disrupts the outer membrane of [[Gram-negative bacteria]] and allows other antibiotics to more effectively penetrate into the cell.<ref>{{cite journal | vauthors = Eckburg PB, Lister T, Walpole S, Keutzer T, Utley L, Tomayko J, Kopp E, Farinola N, Coleman S | title = Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects | journal = Antimicrobial Agents and Chemotherapy | volume = 63 | issue = 9 | date = September 2019 | doi = 10.1128/AAC.00892-19 | pmid = 31262767 | pmc = 6709486 }}</ref><ref>{{cite journal | vauthors = Vaara M | title = Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics | journal = Molecules | volume = 24 | issue = 2 | date = January 2019 | page = 249 | doi = 10.3390/molecules24020249 | doi-access = free | pmid = 30641878 | pmc = 6359160 }}</ref><ref>{{cite journal | vauthors = She P, Liu Y, Xu L, Li Y, Li Z, Liu S, Hussain Z, Wu Y | title = SPR741, Double- or Triple-Combined With Erythromycin and Clarithromycin, Combats Drug-Resistant ''Klebsiella pneumoniae'', Its Biofilms, and Persister Cells | journal = Frontiers in Cellular and Infection Microbiology | date = 2022 | volume = 12 | pages = 858606 | doi = 10.3389/fcimb.2022.858606 | doi-access = free | pmid = 35372124 | pmc = 8971605 }}</ref><ref>{{cite journal | vauthors = Li Z, She P, Liu Y, Xu L, Li Y, Liu S, Hussain Z, Li L, Yang Y, Wu Y | title = Triple combination of SPR741, clarithromycin, and erythromycin against Acinetobacter baumannii and its tolerant phenotype | journal = Journal of Applied Microbiology | volume = 134 | issue = 1 | date = January 2023 | doi = 10.1093/jambio/lxac023 | pmid = 36626755 }}</ref>