Reworked first sentence by changing its structure. Also "negative symptoms" is a psychiatric term, so probably shouldn't be used to mean "unpleasant" in this context.
'''Physical dependence''' refers tois a statephysical resultingcondition fromcaused by chronic use of a [[tolerance]] forming drug thatand hasin which abrupt or producedgradual [[Drugdrug tolerance|tolerancewithdrawal]] andcauses where negativeunpleasant physical symptoms.<ref name="urlDefinitionDefinition of physical dependence - NCI Dictionary of Cancer Terms">{{cite web |url=http://www.cancer.gov/dictionary?cdrid=454765 |title=Definition of physical dependence - NCI Dictionary of Cancer Terms |work= |accessdate=2015-02-18}}</ref> of [[Drug withdrawal|withdrawal]] result from abrupt discontinuation or dosage reduction.<ref>{{cite news | authorlink = | title = All about Addiction | work = | publisher = Medical News Today | url = http://www.medicalnewstoday.com/info/addiction/ | doi = | accessdate = 2015-02-18 }}</ref> Physical dependence can develop from low-dose therapeutic use of certain medications such as benzodiazepines, opioids, antiepileptics and antidepressants, as well as the [[substance abuse|recreational misuse of drugs]] such as alcohol, opioids, and benzodiazepines. The higher the dose used, the greater the duration of use, and the earlier age use began are predictive of worsened physical dependence and thus more severe withdrawal syndromes. Acute withdrawal syndromes can last days, weeks or months. Protracted withdrawal syndrome, also known as [[post-acute-withdrawal syndrome]] or "PAWS," is a low-grade continuation of some of the symptoms of acute withdrawal, typically in a remitting-relapsing pattern, often resulting in [[relapse]] and prolonged disability of a degree to preclude the possibility of lawful employment. Protracted withdrawal syndrome can last for months, years, or depending on individual factors, indefinitely. Protracted withdrawal syndrome is noted to be most often caused by [[benzodiazepines]].<ref name="pmid1575069">{{cite journal |author=Landry MJ, Smith DE, McDuff DR, Baughman OL |title=Benzodiazepine dependence and withdrawal: identification and medical management |journal=J Am Board Fam Pract |volume=5 |issue=2 |pages=167–75 |year=1992 |pmid=1575069 |doi= |url=}}</ref> To dispel the popular misassociation with addiction, physical dependence to medications is sometimes compared to dependence on insulin by persons with diabetes.<ref>{{Cite web|title = Withdrawal From Antidepressants: Symptoms, Causes, Treatments|url = http://www.webmd.com/depression/guide/withdrawal-from-antidepressants|website = WebMD|access-date = 2016-02-20|language = en-US|quote = These symptoms are not technically the same thing as physical "withdrawal" from a drug.... Unlike drug withdrawal, antidepressant discontinuation effects are not related to addiction but can reflect physiological consequences of stopping a drug, just as when someone with diabetes stops insulin.}}</ref>
