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| name = Chromoblastomycosis |
| name = Chromoblastomycosis |
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| synonyms = Chromomycosis,<ref name="Bolognia" /> Cladosporiosis,<ref name="Bolognia" /> Fonseca's disease,<ref name="Bolognia" /> Pedroso's disease,<ref name="Bolognia" /> Phaeosporotrichosis,<ref name="Bolognia" /> or Verrucous dermatitis<ref name="Bolognia">{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}</ref> |
| synonyms = Chromomycosis,<ref name="Bolognia" /> Cladosporiosis,<ref name="Bolognia" /> Fonseca's disease,<ref name="Bolognia" /> Pedroso's disease,<ref name="Bolognia" /> Phaeosporotrichosis,<ref name="Bolognia" /> or Verrucous dermatitis<ref name="Bolognia">{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}</ref> |
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[[File:Chromoblastomycosis.png|thumb|medlar bodies]] |
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| caption2 = Micrograph of chromoblastomycosis showing sclerotic bodies |
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| caption = medlar bodies |
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| pronounce = |
| pronounce = |
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| field = [[Infectious disease (medical specialty)|Infectious disease]], [[Dermatology]] |
| field = [[Infectious disease (medical specialty)|Infectious disease]], [[Dermatology]] |
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| deaths = |
| deaths = |
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<!-- Definition and symptoms --> |
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'''Chromoblastomycosis''' is a long-term [[mycosis|fungal infection]] of the skin<ref>{{DorlandsDict|two/000021022|chromoblastomycosis}}</ref> and [[subcutaneous tissue]] (a [[chronic (medicine)|chronic]] [[subcutaneous mycosis]]).<ref name="pmid17350498">{{cite journal |vauthors=López Martínez R, Méndez Tovar LJ |title=Chromoblastomycosis |journal=Clin. Dermatol. |volume=25 |issue=2 |pages=188–94 |year=2007 |pmid=17350498 |doi=10.1016/j.clindermatol.2006.05.007 }}</ref> The infection occurs most commonly in tropical or subtropical climates, often in rural areas. It can be caused by many different types of [[fungi]] which become implanted under the [[skin]], often by thorns or splinters.<ref>{{Cite web|url=https://rarediseases.info.nih.gov/diseases/1319/chromoblastomycosis|title=Chromoblastomycosis {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program|website=rarediseases.info.nih.gov|language=en|access-date=2018-04-17}}</ref> Chromoblastomycosis spreads very slowly; it is rarely fatal and usually has a good [[prognosis]], but it can be very difficult to cure. The several treatment options include medication and surgery.<ref>{{Cite web|url=https://www.dermnetnz.org/topics/chromoblastomycosis/|title=Chromoblastomycosis {{!}} DermNet New Zealand|website=www.dermnetnz.org|language=en|access-date=2018-04-17}}</ref> |
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'''Chromoblastomycosis''' is a long-term [[mycosis|fungal infection]] of the skin<ref>{{DorlandsDict|two/000021022|chromoblastomycosis}}</ref> and [[subcutaneous tissue]] (a [[chronic (medicine)|chronic]] [[subcutaneous mycosis]]).<ref name="pmid17350498">{{cite journal |vauthors=López Martínez R, Méndez Tovar LJ |title=Chromoblastomycosis |journal=Clin. Dermatol. |volume=25 |issue=2 |pages=188–94 |year=2007 |pmid=17350498 |doi=10.1016/j.clindermatol.2006.05.007 }}</ref> |
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<!-- Cause and mechanism--> |
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==Presentation== |
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It can be caused by many different types of [[fungi]] which become implanted under the [[skin]], often by thorns or splinters.<ref>{{Cite web|url=https://rarediseases.info.nih.gov/diseases/1319/chromoblastomycosis|title=Chromoblastomycosis {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program|website=rarediseases.info.nih.gov|language=en|access-date=2018-04-17|archive-date=2021-03-18|archive-url=https://web.archive.org/web/20210318042348/https://rarediseases.info.nih.gov/diseases/1319/chromoblastomycosis|url-status=dead}}</ref> Chromoblastomycosis spreads very slowly.{{citation needed|date=April 2022}} |
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| ⚫ | [[File:Chromoblastomycosis 2.jpg|thumb|upright=1.35|A 34-year-old man with a 12-year history of chromoblastomycosis and electron micrograph of his skin showing ''Fonsecaea pedrosoi'' spores.<ref>{{cite book |doi=10.5772/61850 |isbn=978-953-51-2252-4 |chapter=Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy |author=Ran Yuping |title=Modern Electron Microscopy in Physical and Life Sciences |editor=Janecek, Milos |editor2=Kral, Robert |publisher=InTech |year=2016}}</ref><!-- This is content from a predatory publisher (intechopen.com); recommend finding an alternative source for a comparable image, but I hesitate to remove the image at this time. -->]] |
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| ⚫ | The initial trauma causing the infection is often forgotten or not noticed. The infection builds at the site over a period of years, and a small red [[papule]] (skin elevation) appears. The lesion is usually not painful, with few, if any symptoms. Patients rarely seek medical care at this point.{{ |
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<!-- Treatment and outcomes --> |
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It is rarely fatal and usually has a good [[prognosis]], but it can be very difficult to cure. The several treatment options include medication and surgery.<ref>{{Cite web|url=https://www.dermnetnz.org/topics/chromoblastomycosis/|title=Chromoblastomycosis {{!}} DermNet New Zealand|website=www.dermnetnz.org|language=en|access-date=2018-04-17}}</ref> |
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<!-- Epidemiology --> |
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The infection occurs most commonly in tropical or subtropical climates, often in rural areas.<ref name="Santos2021">{{cite journal |last1=Santos |first1=Daniel Wagner C. L. |last2=de Azevedo |first2=Conceição de Maria Pedrozo E. Silva |last3=Vicente |first3=Vania Aparecida |last4=Queiroz-Telles |first4=Flávio |last5=Rodrigues |first5=Anderson Messias |last6=de Hoog |first6=G. Sybren |last7=Denning |first7=David W. |last8=Colombo |first8=Arnaldo Lopes |title=The global burden of chromoblastomycosis |journal=PLOS Neglected Tropical Diseases |date=August 2021 |volume=15 |issue=8 |pages=e0009611 |doi=10.1371/journal.pntd.0009611 |pmid=34383752 |issn=1935-2735|pmc=8360387 |doi-access=free }}</ref> |
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==Symptoms and signs== |
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| ⚫ | [[File:Chromoblastomycosis 2.jpg|thumb|upright=1.35|A 34-year-old man with a 12-year history of chromoblastomycosis and electron micrograph of his skin showing ''Fonsecaea pedrosoi'' spores.<ref>{{cite book |doi=10.5772/61850 |isbn=978-953-51-2252-4 |chapter=Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy |author=Ran Yuping |title=Modern Electron Microscopy in Physical and Life Sciences |editor=Janecek, Milos |editor2=Kral, Robert |publisher=InTech |year=2016|s2cid=53472683 }}</ref><!-- This is content from a predatory publisher (intechopen.com); recommend finding an alternative source for a comparable image, but I hesitate to remove the image at this time. -->]] |
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| ⚫ | The initial trauma causing the infection is often forgotten or not noticed. The infection builds at the site over a period of years, and a small red [[papule]] (skin elevation) appears. The lesion is usually not painful, with few, if any symptoms. Patients rarely seek medical care at this point.{{citation needed|date=May 2021}} |
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Several complications may occur. Usually, the infection slowly spreads to the surrounding tissue while still remaining localized to the area around the original wound. However, sometimes the fungi may spread through the [[blood vessels]] or [[lymphatic system|lymph vessels]], producing [[metastatic]] lesions at distant sites. Another possibility is secondary infection with [[bacteria]]. This may lead to [[lymph stasis]] (obstruction of the lymph vessels) and [[Lymphedema|elephantiasis]]. The nodules may become [[Ulcer (dermatology)|ulcerated]], or multiple nodules may grow and coalesce, affecting a large area of a limb.{{citation needed|date=July 2020}} |
Several complications may occur. Usually, the infection slowly spreads to the surrounding tissue while still remaining localized to the area around the original wound. However, sometimes the fungi may spread through the [[blood vessels]] or [[lymphatic system|lymph vessels]], producing [[metastatic]] lesions at distant sites. Another possibility is secondary infection with [[bacteria]]. This may lead to [[lymph stasis]] (obstruction of the lymph vessels) and [[Lymphedema|elephantiasis]]. The nodules may become [[Ulcer (dermatology)|ulcerated]], or multiple nodules may grow and coalesce, affecting a large area of a limb.{{citation needed|date=July 2020}} |
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== |
==Cause== |
||
Chromoblastomycosis is believed to originate in minor trauma to the skin, usually from vegetative material such as thorns or splinters; this trauma implants fungi in the subcutaneous tissue. In many cases, the patient will not notice or remember the initial trauma, as symptoms often do not appear for years. The fungi most commonly observed to cause chromoblastomycosis are: |
Chromoblastomycosis is believed to originate in minor trauma to the skin, usually from vegetative material such as thorns or splinters; this trauma implants fungi in the subcutaneous tissue. In many cases, the patient will not notice or remember the initial trauma, as symptoms often do not appear for years. The fungi most commonly observed to cause chromoblastomycosis are: |
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* ''[[Fonsecaea pedrosoi]]''<ref name="pmid11398635">{{cite journal |vauthors=Bonifaz A, Carrasco-Gerard E, Saúl A |title=Chromoblastomycosis: clinical and mycologic experience of 51 cases |journal=Mycoses |volume=44 |issue=1–2 |pages=1–7 |year=2001 |pmid=11398635 |doi= 10.1046/j.1439-0507.2001.00613.x}}</ref><ref name="pmid17338941">{{cite journal |vauthors=de Andrade TS, Cury AE, de Castro LG, Hirata MH, Hirata RD |title=Rapid identification of Fonsecaea by duplex polymerase chain reaction in isolates from patients with chromoblastomycosis |journal=Diagn. Microbiol. Infect. Dis. |volume=57 |issue=3 |pages=267–72 |date=March 2007 |pmid=17338941 |doi=10.1016/j.diagmicrobio.2006.08.024 }}</ref> |
* ''[[Fonsecaea pedrosoi]]''<ref name="pmid11398635">{{cite journal |vauthors=Bonifaz A, Carrasco-Gerard E, Saúl A |title=Chromoblastomycosis: clinical and mycologic experience of 51 cases |journal=Mycoses |volume=44 |issue=1–2 |pages=1–7 |year=2001 |pmid=11398635 |doi= 10.1046/j.1439-0507.2001.00613.x|s2cid=9606451 }}</ref><ref name="pmid17338941">{{cite journal |vauthors=de Andrade TS, Cury AE, de Castro LG, Hirata MH, Hirata RD |title=Rapid identification of Fonsecaea by duplex polymerase chain reaction in isolates from patients with chromoblastomycosis |journal=Diagn. Microbiol. Infect. Dis. |volume=57 |issue=3 |pages=267–72 |date=March 2007 |pmid=17338941 |doi=10.1016/j.diagmicrobio.2006.08.024 }}</ref> |
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* ''[[Cladophialophora bantiana]]'' causes both cutaneous chromoblastomycosis and systemic [[phaeohyphomycosis]] |
* ''[[Cladophialophora bantiana]]'' causes both cutaneous chromoblastomycosis and systemic [[phaeohyphomycosis]] |
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* ''[[Phialophora verrucosa]]''<ref name="pmid15787829">{{cite journal |vauthors=Park SG, Oh SH, Suh SB, Lee KH, Chung KY |title=A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine |journal=Br. J. Dermatol. |volume=152 |issue=3 |pages=560–4 |date=March 2005 |pmid=15787829 |doi=10.1111/j.1365-2133.2005.06424.x |s2cid=41788722 }}</ref> |
* ''[[Phialophora verrucosa]]''<ref name="pmid15787829">{{cite journal |vauthors=Park SG, Oh SH, Suh SB, Lee KH, Chung KY |title=A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine |journal=Br. J. Dermatol. |volume=152 |issue=3 |pages=560–4 |date=March 2005 |pmid=15787829 |doi=10.1111/j.1365-2133.2005.06424.x |s2cid=41788722 }}</ref> |
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* ''[[Fonsecaea compacta]]''<ref name="pmid9368408">{{cite journal |author=Attapattu MC |s2cid=26091759 |title=Chromoblastomycosis--a clinical and mycological study of 71 cases from Sri Lanka |journal=Mycopathologia |volume=137 |issue=3 |pages=145–51 |year=1997 |pmid=9368408 |doi= 10.1023/A:1006819530825}}</ref> |
* ''[[Fonsecaea compacta]]''<ref name="pmid9368408">{{cite journal |author=Attapattu MC |s2cid=26091759 |title=Chromoblastomycosis--a clinical and mycological study of 71 cases from Sri Lanka |journal=Mycopathologia |volume=137 |issue=3 |pages=145–51 |year=1997 |pmid=9368408 |doi= 10.1023/A:1006819530825}}</ref> |
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==Mechanism== |
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Over months to years, an erythematous papule appears at the site of inoculation. Although the mycosis slowly spreads, it usually remains localized to the skin and subcutaneous tissue. Hematogenous and/or lymphatic spread may occur. Multiple nodules may appear on the same limb, sometimes coalescing into a large plaque. Secondary bacterial infection may occur, sometimes inducing lymphatic obstruction. The central portion of the lesion may heal, producing a scar, or it may ulcerate.{{citation needed|date=July 2020}} |
Over months to years, an erythematous papule appears at the site of inoculation. Although the mycosis slowly spreads, it usually remains localized to the skin and subcutaneous tissue. Hematogenous and/or lymphatic spread may occur. Multiple nodules may appear on the same limb, sometimes coalescing into a large plaque. Secondary bacterial infection may occur, sometimes inducing lymphatic obstruction. The central portion of the lesion may heal, producing a scar, or it may ulcerate.{{citation needed|date=July 2020}} |
||
==Diagnosis== |
==Diagnosis== |
||
The most informative test is to scrape the lesion and add [[potassium hydroxide]] (KOH), then examine under a microscope. (KOH scrapings are commonly used to examine fungal infections.) The [[pathognomonic]] finding is observing [[medlar bodies]] (also called muriform bodies or sclerotic cells). Scrapings from the lesion can also be [[microbiological culture|cultured]] to identify the organism involved. Blood tests and imaging studies are not commonly used.On histology, chromoblastomycosis manifests as pigmented yeasts resembling "copper pennies". Special stains, such as periodic acid schiff and Gömöri methenamine silver, can be used to demonstrate the fungal organisms if needed.{{citation needed|date=July 2020}} |
The most informative test is to scrape the lesion and add [[potassium hydroxide]] (KOH), then examine under a microscope. (KOH scrapings are commonly used to examine fungal infections.) The [[pathognomonic]] finding is observing [[medlar bodies]] (also called muriform bodies or sclerotic cells). Scrapings from the lesion can also be [[microbiological culture|cultured]] to identify the organism involved. Blood tests and imaging studies are not commonly used. On histology, chromoblastomycosis manifests as pigmented yeasts resembling "copper pennies". Special stains, such as periodic acid schiff and Gömöri methenamine silver, can be used to demonstrate the fungal organisms if needed.{{citation needed|date=July 2020}} |
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==Prevention== |
==Prevention== |
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==Treatment== |
==Treatment== |
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Chromoblastomycosis is very difficult to cure. The primary treatments of choice are:{{ |
Chromoblastomycosis is very difficult to cure. The primary treatments of choice are:{{citation needed|date=May 2021}} |
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* [[Itraconazole]], an [[Antifungal medication|antifungal]] [[azole]], is given orally, with or without [[flucytosine]]. |
* [[Itraconazole]], an [[Antifungal medication|antifungal]] [[azole]], is given orally, with or without [[flucytosine]]. |
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* Alternatively, [[cryosurgery]] with [[liquid nitrogen]] has also been shown to be effective. |
* Alternatively, [[cryosurgery]] with [[liquid nitrogen]] has also been shown to be effective. |
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Other treatment options are the antifungal drug [[terbinafine]],<ref name="pmid15897168">{{cite journal |vauthors=Bonifaz A, Saúl A, Paredes-Solis V, Araiza J, Fierro-Arias L |s2cid=45956388 |title=Treatment of chromoblastomycosis with terbinafine: experience with four cases |journal=J Dermatolog Treat |volume=16 |issue=1 |pages=47–51 |date=February 2005 |pmid=15897168 |doi=10.1080/09546630410024538 |url=https://zenodo.org/record/894429 }}</ref> another antifungal azole [[posaconazole]], and [[heat therapy]]. |
Other treatment options are the antifungal drug [[terbinafine]],<ref name="pmid15897168">{{cite journal |vauthors=Bonifaz A, Saúl A, Paredes-Solis V, Araiza J, Fierro-Arias L |s2cid=45956388 |title=Treatment of chromoblastomycosis with terbinafine: experience with four cases |journal=J Dermatolog Treat |volume=16 |issue=1 |pages=47–51 |date=February 2005 |pmid=15897168 |doi=10.1080/09546630410024538 |url=https://zenodo.org/record/894429 }}</ref> another antifungal azole [[posaconazole]], and [[heat therapy]]. |
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[[Antibiotics]] may be used to treat bacterial superinfections.{{ |
[[Antibiotics]] may be used to treat bacterial superinfections.{{citation needed|date=May 2021}} |
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[[Amphotericin B]] has also been used.<ref name="pmid18324498">{{cite journal |vauthors=Paniz-Mondolfi AE, Colella MT, Negrín DC |title=Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole |journal=Med. Mycol. |volume=46 |issue=2 |pages=179–84 |date=March 2008 |pmid=18324498 |doi=10.1080/13693780701721856 |doi-access=free }}</ref> |
[[Amphotericin B]] has also been used.<ref name="pmid18324498">{{cite journal |vauthors=Paniz-Mondolfi AE, Colella MT, Negrín DC |title=Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole |journal=Med. Mycol. |volume=46 |issue=2 |pages=179–84 |date=March 2008 |pmid=18324498 |doi=10.1080/13693780701721856 |doi-access=free }}</ref> |
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Photodynamic therapy is a newer type of therapy used to treat Chromblastomycosis.<ref>{{Cite journal |last1=Queiroz-Telles |first1=Flavio |last2=de C L Santos |first2=Daniel Wagner |date=2013-06-01 |title=Challenges in the Therapy of Chromoblastomycosis |url=https://doi.org/10.1007/s11046-013-9648-x |journal=Mycopathologia |language=en |volume=175 |issue=5 |pages=477–488 |doi=10.1007/s11046-013-9648-x |pmid=23636730 |s2cid=14417993 |issn=1573-0832}}</ref> |
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==Prognosis== |
==Prognosis== |
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==Epidemiology== |
==Epidemiology== |
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Chromoblastomycosis occurs around the world, most commonly in rural areas in tropical or subtropical climates.<ref name="Santos2021"/> |
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Chromoblastomycosis occurs around the world, but is most common in rural areas between approximately 30°N and 30°S [[latitude]]. [[Madagascar]] and [[Japan]] have the highest incidence. Over two-thirds of patients are [[male]], and usually between the ages of 30 and 50. A correlation with [[human leukocyte antigen|HLA]]-A29 suggests genetic factors may play a role, as well.{{citation needed|date=July 2020}} |
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It is most common in rural areas between approximately 30°N and 30°S [[latitude]]. Over two-thirds of patients are [[male]], and usually between the ages of 30 and 50. A correlation with [[human leukocyte antigen|HLA]]-A29 suggests genetic factors may play a role, as well.<ref>{{Cite journal |last1=Queiroz-Telles |first1=Flavio |last2=de Hoog |first2=Sybren |last3=Santos |first3=Daniel Wagner C. L. |last4=Salgado |first4=Claudio Guedes |last5=Vicente |first5=Vania Aparecida |last6=Bonifaz |first6=Alexandro |last7=Roilides |first7=Emmanuel |last8=Xi |first8=Liyan |last9=Azevedo |first9=Conceição de Maria Pedrozo E. Silva |last10=da Silva |first10=Moises Batista |last11=Pana |first11=Zoe Dorothea |date=January 2017 |title=Chromoblastomycosis |journal=Clinical Microbiology Reviews |volume=30 |issue=1 |pages=233–276 |doi=10.1128/CMR.00032-16 |issn=1098-6618 |pmc=5217794 |pmid=27856522}}</ref> |
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==Social and cultural== |
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Chromoblastomycosis is considered a [[neglected tropical disease]], affects mainly people living in poverty, and causes considerable [[morbidity]], stigma and discrimination.<ref name="Santos2021"/> |
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== See also == |
== See also == |
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== External links == |
== External links == |
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{{Medical resources |
{{Medical resources |
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| DiseasesDB = 29799 |
| DiseasesDB = 29799 |
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| ICD10 = {{ICD10|B|43||b|35}} |
| ICD10 = {{ICD10|B|43||b|35}} |
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| ICD9 = {{ICD9|117.2}} |
| ICD9 = {{ICD9|117.2}} |
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| ICDO = |
| ICDO = |
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| OMIM = |
| OMIM = |
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| MedlinePlus = |
| MedlinePlus = |
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| eMedicineSubj = derm |
| eMedicineSubj = derm |
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| eMedicineTopic = 855 |
| eMedicineTopic = 855 |
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| MeshID = D002862 |
| MeshID = D002862 |
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}} |
}} |
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[[Category:Mycosis-related cutaneous conditions]] |
[[Category:Mycosis-related cutaneous conditions]] |
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| ⚫ | |||
[[Category:Tropical diseases]] |
[[Category:Tropical diseases]] |
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| ⚫ | |||
Latest revision as of 19:26, 11 October 2023
| Chromoblastomycosis | |
|---|---|
| Other names | Chromomycosis,[1] Cladosporiosis,[1] Fonseca's disease,[1] Pedroso's disease,[1] Phaeosporotrichosis,[1] or Verrucous dermatitis[1] |
 | |
| Micrograph of chromoblastomycosis showing sclerotic bodies | |
| Specialty | Infectious disease, Dermatology |
Chromoblastomycosis is a long-term fungal infection of the skin[2] and subcutaneous tissue (a chronic subcutaneous mycosis).[3]
It can be caused by many different types of fungi which become implanted under the skin, often by thorns or splinters.[4] Chromoblastomycosis spreads very slowly.[citation needed]
It is rarely fatal and usually has a good prognosis, but it can be very difficult to cure. The several treatment options include medication and surgery.[5]
The infection occurs most commonly in tropical or subtropical climates, often in rural areas.[6]
Symptoms and signs
[edit]
The initial trauma causing the infection is often forgotten or not noticed. The infection builds at the site over a period of years, and a small red papule (skin elevation) appears. The lesion is usually not painful, with few, if any symptoms. Patients rarely seek medical care at this point.[citation needed]
Several complications may occur. Usually, the infection slowly spreads to the surrounding tissue while still remaining localized to the area around the original wound. However, sometimes the fungi may spread through the blood vessels or lymph vessels, producing metastatic lesions at distant sites. Another possibility is secondary infection with bacteria. This may lead to lymph stasis (obstruction of the lymph vessels) and elephantiasis. The nodules may become ulcerated, or multiple nodules may grow and coalesce, affecting a large area of a limb.[citation needed]
Cause
[edit]Chromoblastomycosis is believed to originate in minor trauma to the skin, usually from vegetative material such as thorns or splinters; this trauma implants fungi in the subcutaneous tissue. In many cases, the patient will not notice or remember the initial trauma, as symptoms often do not appear for years. The fungi most commonly observed to cause chromoblastomycosis are:
- Fonsecaea pedrosoi[8][9]
- Cladophialophora bantiana causes both cutaneous chromoblastomycosis and systemic phaeohyphomycosis
- Phialophora verrucosa[10]
- Cladophialophora carrionii
- Fonsecaea compacta[11]
Mechanism
[edit]Over months to years, an erythematous papule appears at the site of inoculation. Although the mycosis slowly spreads, it usually remains localized to the skin and subcutaneous tissue. Hematogenous and/or lymphatic spread may occur. Multiple nodules may appear on the same limb, sometimes coalescing into a large plaque. Secondary bacterial infection may occur, sometimes inducing lymphatic obstruction. The central portion of the lesion may heal, producing a scar, or it may ulcerate.[citation needed]
Diagnosis
[edit]The most informative test is to scrape the lesion and add potassium hydroxide (KOH), then examine under a microscope. (KOH scrapings are commonly used to examine fungal infections.) The pathognomonic finding is observing medlar bodies (also called muriform bodies or sclerotic cells). Scrapings from the lesion can also be cultured to identify the organism involved. Blood tests and imaging studies are not commonly used. On histology, chromoblastomycosis manifests as pigmented yeasts resembling "copper pennies". Special stains, such as periodic acid schiff and Gömöri methenamine silver, can be used to demonstrate the fungal organisms if needed.[citation needed]
Prevention
[edit]No preventive measure is known aside from avoiding the traumatic inoculation of fungi. At least one study found a correlation between walking barefoot in endemic areas and occurrence of chromoblastomycosis on the foot.[citation needed]
Treatment
[edit]Chromoblastomycosis is very difficult to cure. The primary treatments of choice are:[citation needed]
- Itraconazole, an antifungal azole, is given orally, with or without flucytosine.
- Alternatively, cryosurgery with liquid nitrogen has also been shown to be effective.
Other treatment options are the antifungal drug terbinafine,[12] another antifungal azole posaconazole, and heat therapy.
Antibiotics may be used to treat bacterial superinfections.[citation needed]
Amphotericin B has also been used.[13]
Photodynamic therapy is a newer type of therapy used to treat Chromblastomycosis.[14]
Prognosis
[edit]The prognosis for chromoblastomycosis is very good for small lesions. Severe cases are difficult to cure, although the prognosis is still quite good. The primary complications are ulceration, lymphedema, and secondary bacterial infection. A few cases of malignant transformation to squamous cell carcinoma have been reported. Chromoblastomycosis is very rarely fatal.[citation needed]
Epidemiology
[edit]Chromoblastomycosis occurs around the world, most commonly in rural areas in tropical or subtropical climates.[6]
It is most common in rural areas between approximately 30°N and 30°S latitude. Over two-thirds of patients are male, and usually between the ages of 30 and 50. A correlation with HLA-A29 suggests genetic factors may play a role, as well.[15]
Social and cultural
[edit]Chromoblastomycosis is considered a neglected tropical disease, affects mainly people living in poverty, and causes considerable morbidity, stigma and discrimination.[6]
See also
[edit]References
[edit]- ^ a b c d e f Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ "chromoblastomycosis" at Dorland's Medical Dictionary
- ^ López Martínez R, Méndez Tovar LJ (2007). "Chromoblastomycosis". Clin. Dermatol. 25 (2): 188–94. doi:10.1016/j.clindermatol.2006.05.007. PMID 17350498.
- ^ "Chromoblastomycosis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 2021-03-18. Retrieved 2018-04-17.
- ^ "Chromoblastomycosis | DermNet New Zealand". www.dermnetnz.org. Retrieved 2018-04-17.
- ^ a b c Santos, Daniel Wagner C. L.; de Azevedo, Conceição de Maria Pedrozo E. Silva; Vicente, Vania Aparecida; Queiroz-Telles, Flávio; Rodrigues, Anderson Messias; de Hoog, G. Sybren; Denning, David W.; Colombo, Arnaldo Lopes (August 2021). "The global burden of chromoblastomycosis". PLOS Neglected Tropical Diseases. 15 (8): e0009611. doi:10.1371/journal.pntd.0009611. ISSN 1935-2735. PMC 8360387. PMID 34383752.
- ^ Ran Yuping (2016). "Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy". In Janecek, Milos; Kral, Robert (eds.). Modern Electron Microscopy in Physical and Life Sciences. InTech. doi:10.5772/61850. ISBN 978-953-51-2252-4. S2CID 53472683.
- ^ Bonifaz A, Carrasco-Gerard E, Saúl A (2001). "Chromoblastomycosis: clinical and mycologic experience of 51 cases". Mycoses. 44 (1–2): 1–7. doi:10.1046/j.1439-0507.2001.00613.x. PMID 11398635. S2CID 9606451.
- ^ de Andrade TS, Cury AE, de Castro LG, Hirata MH, Hirata RD (March 2007). "Rapid identification of Fonsecaea by duplex polymerase chain reaction in isolates from patients with chromoblastomycosis". Diagn. Microbiol. Infect. Dis. 57 (3): 267–72. doi:10.1016/j.diagmicrobio.2006.08.024. PMID 17338941.
- ^ Park SG, Oh SH, Suh SB, Lee KH, Chung KY (March 2005). "A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine". Br. J. Dermatol. 152 (3): 560–4. doi:10.1111/j.1365-2133.2005.06424.x. PMID 15787829. S2CID 41788722.
- ^ Attapattu MC (1997). "Chromoblastomycosis--a clinical and mycological study of 71 cases from Sri Lanka". Mycopathologia. 137 (3): 145–51. doi:10.1023/A:1006819530825. PMID 9368408. S2CID 26091759.
- ^ Bonifaz A, Saúl A, Paredes-Solis V, Araiza J, Fierro-Arias L (February 2005). "Treatment of chromoblastomycosis with terbinafine: experience with four cases". J Dermatolog Treat. 16 (1): 47–51. doi:10.1080/09546630410024538. PMID 15897168. S2CID 45956388.
- ^ Paniz-Mondolfi AE, Colella MT, Negrín DC (March 2008). "Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole". Med. Mycol. 46 (2): 179–84. doi:10.1080/13693780701721856. PMID 18324498.
- ^ Queiroz-Telles, Flavio; de C L Santos, Daniel Wagner (2013-06-01). "Challenges in the Therapy of Chromoblastomycosis". Mycopathologia. 175 (5): 477–488. doi:10.1007/s11046-013-9648-x. ISSN 1573-0832. PMID 23636730. S2CID 14417993.
- ^ Queiroz-Telles, Flavio; de Hoog, Sybren; Santos, Daniel Wagner C. L.; Salgado, Claudio Guedes; Vicente, Vania Aparecida; Bonifaz, Alexandro; Roilides, Emmanuel; Xi, Liyan; Azevedo, Conceição de Maria Pedrozo E. Silva; da Silva, Moises Batista; Pana, Zoe Dorothea (January 2017). "Chromoblastomycosis". Clinical Microbiology Reviews. 30 (1): 233–276. doi:10.1128/CMR.00032-16. ISSN 1098-6618. PMC 5217794. PMID 27856522.
External links
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