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{{Short description|Stimulant}}
{{Drugbox|Verifiedfields=changed|Watchedfields=changed|verifiedrevid=443690999|IUPAC_name=(3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate|image=Dimethocaine-structure.svg|width=200
{{distinguish|Dimethicone}}
<!--Clinical data-->|tradename=|routes_of_administration=|legal_DE=Anlage II<!--Identifiers-->|CAS_number_Ref={{cascite|correct|??}}|CAS_number=94-15-5|CAS_supplemental=<br>553-63-9 ([[hydrochloride|HCl]])|ATC_prefix=none|ATC_suffix=|PubChem=7177|DrugBank_Ref={{drugbankcite|correct|drugbank}}|UNII_Ref={{fdacite|correct|FDA}}|UNII=R3L4A6GOWZ|smiles=NC1=CC=C(C(OCC(C)(C)CN(CC)CC)=O)C=C1|ChemSpiderID_Ref={{chemspidercite|changed|chemspider}}|ChemSpiderID=6909|StdInChI_Ref={{stdinchicite|changed|chemspider}}|StdInChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3|StdInChIKey_Ref={{stdinchicite|changed|chemspider}}|StdInChIKey=OWQIUQKMMPDHQQ-UHFFFAOYSA-N
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<!--Chemical data-->|C=16|H=26|N=2|O=2|molecular_weight=278.39 g/mol|melting_point=48|melting_high=51|drug_name=Dimethocaine|alt=|caption=|type=|MedlinePlus=|legal_status=|licence_EU=|pregnancy_AU=|pregnancy_US=|pregnancy_category=|licence_US=|DrugBank=|synonyms=DMC, larocaine|density=1.0±0.1|density_notes=(predicted)|melting_notes=(experimental)|boiling_point=334|boiling_high=403|boiling_notes=at 760 mmHg}}'''Dimethocaine''', also known as '''DMC''' or '''larocaine''', is a compound with a stimulatory effect. This effect resembles that of [[cocaine]], although dimethocaine appears to be less potent. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the [[European Monitoring Centre for Drugs and Drug Addiction]] (EMCDDA) under the category “synthetic cocaine derivatives”.<ref name="Meyer_2014">{{cite journal | vauthors = Meyer MR, Lindauer C, Welter J, Maurer HH | title = Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry | journal = Analytical and Bioanalytical Chemistry | volume = 406 | issue = 7 | pages = 1845–54 | date = March 2014 | pmid = 24448968 | doi = 10.1007/s00216-013-7539-0 }}</ref> The structure of dimethocaine, being a benzoic ester acid, resembles that of [[procaine]]. It is found as a white powder at room temperature.<ref name="Dargan_2013">{{cite book | url = https://books.google.com/?id=8psTrw4GokAC&pg=PA406&lpg=PA406&dq=dimethocaine+toxicity#v=onepage&q=dimethocaine%20toxicity&f=false|title=Novel Psychoactive Substances: Classification, Pharmacology and Toxicology|last=Dargan|first=Paul|last2=Wood|first2=David | name-list-format = vanc |date=2013-08-06|publisher=Elsevier/Academic Press|location=Amsterdam |isbn=978-0-12-415911-2}}</ref>
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<!--Chemical data-->
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When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to in fact be a mixture of [[caffeine]] and [[lidocaine]],<ref>{{cite journal | vauthors = Brandt SD, Sumnall HR, Measham F, Cole J | title = Second generation mephedrone. The confusing case of NRG-1 | journal = BMJ | volume = 341 | pages = c3564 | date = July 2010 | pmid = 20605894 | doi = 10.1136/bmj.c3564 }}</ref> and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded "bath salt" product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.<ref>[http://www.nacd.ie/publications/Head_Report2011_overview.pdf An overview of new psychoactive substances and the outlets supplying them] {{webarchive|url=https://web.archive.org/web/20111125000000/http://www.nacd.ie/publications/Head_Report2011_overview.pdf|date=November 25, 2011}}</ref>
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|synonyms=DMC, larocaine
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⚫
'''Dimethocaine''', also known as '''DMC''' or '''larocaine''', is a compound with a stimulatory effect. This effect resembles that of [[cocaine]], although dimethocaine appears to be less potent. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the [[European Monitoring Centre for Drugs and Drug Addiction]] (EMCDDA) under the category “synthetic cocaine derivatives”.<ref name="Meyer_2014">{{cite journal | vauthors = Meyer MR, Lindauer C, Welter J, Maurer HH | title = Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry | journal = Analytical and Bioanalytical Chemistry | volume = 406 | issue = 7 | pages = 1845–54 | date = March 2014 | pmid = 24448968 | doi = 10.1007/s00216-013-7539-0 | s2cid = 10850370 }}</ref> The structure of dimethocaine, being a [[4-aminobenzoic acid]] ester, resembles that of [[procaine]]. It is found as a white powder at room temperature.<ref name="Dargan_2013">{{cite book | url = https://books.google.com/books?id=8psTrw4GokAC&q=dimethocaine+toxicity&pg=PA406|title=Novel Psychoactive Substances: Classification, Pharmacology and Toxicology| vauthors = Dargan P, Wood D |date=2013-08-06|publisher=Elsevier/Academic Press|location=Amsterdam |isbn=978-0-12-415911-2}}</ref>

⚫
When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to be a mixture of [[caffeine]] and [[lidocaine]],<ref>{{cite journal | vauthors = Brandt SD, Sumnall HR, Measham F, Cole J | title = Second generation mephedrone. The confusing case of NRG-1 | journal = BMJ | volume = 341 | pages = c3564 | date = July 2010 | pmid = 20605894 | doi = 10.1136/bmj.c3564 | s2cid = 20354123 }}</ref> and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded "bath salt" product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.<ref>[http://www.nacd.ie/publications/Head_Report2011_overview.pdf An overview of new psychoactive substances and the outlets supplying them] {{webarchive|url=https://web.archive.org/web/20111125050141/http://www.nacd.ie/publications/Head_Report2011_overview.pdf|date=November 25, 2011}}</ref>


== History ==
== History ==
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=== Pharmacodynamics ===
=== Pharmacodynamics ===
Dimethocaine and structurally related local anesthetics like cocaine and procaine are suggested to inhibit the uptake of [[dopamine]] (DA) by blocking [[dopamine transporter]]s (DAT).<ref name="Woodward_1995">{{cite journal | vauthors = Woodward JJ, Compton DM, Balster RL, Martin BR | title = In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter | journal = European Journal of Pharmacology | volume = 277 | issue = 1 | pages = 7–13 | date = April 1995 | pmid = 7635175 | doi = 10.1016/0014-2999(95)00042-J }}</ref> The dopamine transporter controls the dynamics of the [[neurotransmitter]] dopamine. This neurotransmitter controls many functions including movement, cognition and mood. Drug like cocaine and dimethocaine induce dopamine overflow by inhibiting dopamine transporters and thus creating a euphoric effect.<ref>{{cite journal | vauthors = Vaughan RA, Foster JD | title = Mechanisms of dopamine transporter regulation in normal and disease states | journal = Trends in Pharmacological Sciences | volume = 34 | issue = 9 | pages = 489–96 | date = September 2013 | pmid = 23968642 | pmc = 3831354 | doi = 10.1016/j.tips.2013.07.005 }}</ref> In addition to inhibiting dopamine uptake, dimethocaine was also shown to inhibit the binding of [[WIN-35428|CFT]], a different dopamine uptake inhibitor.<ref name="Woodward_1995" /> These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the [[central nervous system]].<ref name="Lindauer_2014" /> Both ''[[in vivo]]'' and ''[[in vitro]]'' measurements of dopamine transporter activity showed that dimethocaine is a potent and efficacious dopaminergic antagonist.<ref name="Woodward_1995" /> These effects were mainly observed in the [[nucleus accumbens]], a region in the [[basal forebrain]].<ref name="Lindauer_2014" /> Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:<ref name="Lindauer_2014" />
Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of [[dopamine]] (DA) by blocking [[dopamine transporter]]s (DAT).<ref name="Woodward_1995">{{cite journal | vauthors = Woodward JJ, Compton DM, Balster RL, Martin BR | title = In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter | journal = European Journal of Pharmacology | volume = 277 | issue = 1 | pages = 7–13 | date = April 1995 | pmid = 7635175 | doi = 10.1016/0014-2999(95)00042-J }}</ref> The dopamine transporter controls the dynamics of the [[neurotransmitter]] dopamine. This neurotransmitter controls many functions including movement, cognition and mood. Drugs such as cocaine and dimethocaine induce dopamine overflow by inhibiting dopamine transporters and thus creating a euphoric effect.<ref>{{cite journal | vauthors = Vaughan RA, Foster JD | title = Mechanisms of dopamine transporter regulation in normal and disease states | journal = Trends in Pharmacological Sciences | volume = 34 | issue = 9 | pages = 489–96 | date = September 2013 | pmid = 23968642 | pmc = 3831354 | doi = 10.1016/j.tips.2013.07.005 }}</ref> In addition to inhibiting dopamine uptake, dimethocaine was also shown to inhibit the binding of [[WIN-35428|CFT]], a different dopamine uptake inhibitor.<ref name="Woodward_1995" /> These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the [[central nervous system]].<ref name="Lindauer_2014" /> Both ''[[in vivo]]'' and ''[[in vitro]]'' measurements of dopamine transporter activity showed that dimethocaine is a potent and efficacious dopaminergic reuptake inhibitor (also called a dopamine indirect agonist).<ref name="Woodward_1995" /> These effects were mainly observed in the [[nucleus accumbens]], a region in the [[basal forebrain]].<ref name="Lindauer_2014" /> Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:<ref name="Lindauer_2014" />


cocaine > dimethocaine > [[tetracaine]] > procaine > [[chloroprocaine]]
cocaine > dimethocaine > [[tetracaine]] > procaine > [[chloroprocaine]]


Furthermore, the administration of dimethocaine has been shown to lead to [[Nociception|antinociceptive]] responses at nontoxic doses in mice.<ref name="Rigon_1996">{{cite journal | vauthors = Rigon AR, Takahashi RN | title = The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice | journal = General Pharmacology | volume = 27 | issue = 4 | pages = 647–50 | date = June 1996 | pmid = 8853299 | doi = 10.1016/0306-3623(95)02079-9 }}</ref> These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system. A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.<ref name="Blatt_1998">{{cite journal | vauthors = Blatt SL, Takahashi RN | title = Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice | journal = Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas | volume = 31 | issue = 4 | pages = 555–9 | date = April 1998 | pmid = 9698809 | doi = | url = http://www.scielo.br/pdf/bjmbr/v31n4/2882c.pdf }}</ref>
Furthermore, the administration of dimethocaine has been shown to lead to [[Nociception|antinociceptive]] responses at nontoxic doses in mice.<ref name="Rigon_1996">{{cite journal | vauthors = Rigon AR, Takahashi RN | title = The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice | journal = General Pharmacology | volume = 27 | issue = 4 | pages = 647–50 | date = June 1996 | pmid = 8853299 | doi = 10.1016/0306-3623(95)02079-9 }}</ref> These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system. A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.<ref name="Blatt_1998">{{cite journal | vauthors = Blatt SL, Takahashi RN | title = Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice | journal = Brazilian Journal of Medical and Biological Research | volume = 31 | issue = 4 | pages = 555–9 | date = April 1998 | pmid = 9698809 | doi = 10.1590/s0100-879x1998000400013| url = http://www.scielo.br/pdf/bjmbr/v31n4/2882c.pdf | doi-access = free }}</ref>


=== Pharmacokinetics ===
=== Pharmacokinetics ===
When inhaled, dimethocaine starts working in 10–30 minutes, with highest effects at 60–120 minutes and until 4–6 hours there is a period of action with the ‘after-effects’.<ref>{{Cite book|url=https://doi.org/10.1016/B978-0-12-415816-0.00017-1|title=Miscellaneous Compounds|last=Greene|first=Shaun L.|pages=393–409|doi=10.1016/b978-0-12-415816-0.00017-1}}</ref> The after effects include fatigue and slight mental impairment.<ref name="TDC" />
When inhaled, dimethocaine starts working in 10–30 minutes, with highest effects at 60–120 minutes and until 4–6 hours there is a period of action with the ‘after-effects’.<ref>{{Cite book| vauthors = Greene SL |pages=393–409|doi=10.1016/b978-0-12-415816-0.00017-1|chapter = Miscellaneous Compounds|title = Novel Psychoactive Substances|year = 2013|isbn = 9780124158160}}</ref> The after effects include fatigue and slight mental impairment.<ref name="TDC" />


== Metabolism ==
== Metabolism ==
The exact metabolic pathways of dimethocaine have not been researched, but the different metabolites have been examined in [[Laboratory rat|Wistar rats]]. After administration of dimethocaine, different metabolites have been found and identified in their urine. Due to these metabolites, different metabolic pathways could have been postulated. The main [[Drug metabolism|phase I]] reactions are [[ester hydrolysis]], [[Demethylation|deethylation,]] [[hydroxylation]] of the aromatic system, or a combination of these three.<ref name="Meyer_2014" /> The main [[Drug metabolism|phase II]] reactions are [[Acetylation|N-acetylation]], [[glucuronidation]] and a combination of both.<ref name="Lindauer_2014" /><ref name="Meyer_2014" /> Different [[cytochrome P450]] [[isozyme]]s are involved in the initial steps of human metabolism. The N-acetylation is catalyzed by the [[N-acetyltransferase 2|NAT2]] isozyme.<ref>{{cite journal | vauthors = Meyer MR, Lindauer C, Maurer HH | title = Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2 | journal = Toxicology Letters | volume = 225 | issue = 1 | pages = 139–46 | date = February 2014 | pmid = 24309420 | doi = 10.1016/j.toxlet.2013.11.033 | url = https://doi.org/10.1016/j.toxlet.2013.11.033 }}</ref>
The exact metabolic pathways of dimethocaine have not been researched, but the different metabolites have been examined in [[Laboratory rat|Wistar rats]]. After administration of dimethocaine, different metabolites have been found and identified in their urine. Due to these metabolites, different metabolic pathways could have been postulated. The main [[Drug metabolism|phase I]] reactions are [[ester hydrolysis]], [[Demethylation|deethylation]], [[hydroxylation]] of the aromatic system, or a combination of these three.<ref name="Meyer_2014" /> The main [[Drug metabolism|phase II]] reactions are [[Acetylation|N-acetylation]], [[glucuronidation]] and a combination of both.<ref name="Lindauer_2014" /><ref name="Meyer_2014" /> Different [[cytochrome P450]] [[isozyme]]s are involved in the initial steps of human metabolism. The N-acetylation is catalyzed by the [[N-acetyltransferase 2|NAT2]] isozyme.<ref>{{cite journal | vauthors = Meyer MR, Lindauer C, Maurer HH | title = Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2 | journal = Toxicology Letters | volume = 225 | issue = 1 | pages = 139–46 | date = February 2014 | pmid = 24309420 | doi = 10.1016/j.toxlet.2013.11.033 }}</ref>


== Efficacy and side effects ==
== Efficacy and side effects ==
Just like cocaine, dimethocaine inhibits the uptake of dopamine in the brain by interfering with the dopamine transporters.<ref name="Wilcox_2005">{{cite journal | vauthors = Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL | title = In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys | journal = Synapse | volume = 58 | issue = 4 | pages = 220–8 | date = December 2005 | pmid = 16206183 | doi = 10.1002/syn.20199 }}</ref> The potency of these drugs is linked to their affinity for the dopamine transporters, and their potency to inhibit dopamine uptake.<ref name="Woodward_1995" />
Just like cocaine, dimethocaine inhibits the uptake of dopamine in the brain by interfering with the dopamine transporters.<ref name="Wilcox_2005">{{cite journal | vauthors = Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL | title = In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys | journal = Synapse | volume = 58 | issue = 4 | pages = 220–8 | date = December 2005 | pmid = 16206183 | doi = 10.1002/syn.20199 | citeseerx = 10.1.1.327.1264 | s2cid = 15631376 }}</ref> The potency of these drugs is linked to their affinity for the dopamine transporters, and their potency to inhibit dopamine uptake.<ref name="Woodward_1995" />


In studies with [[Rhesus macaque|rhesus monkeys]] the affinity of dimethocaine for dopamine transporters is smaller than that of cocaine, whereas dimethocaine's potency to inhibit dopamine uptake is similar. This means that more of dimethocaine is needed to reach a similar response. The peak effects occurred within 10 to 20 minutes after the injection and decreased to baseline levels within an hour.<ref name="Wilcox_2005" />
In studies with [[Rhesus macaque|rhesus monkeys]] the affinity of dimethocaine for dopamine transporters is smaller than that of cocaine, whereas dimethocaine's potency to inhibit dopamine uptake is similar. This means that more of dimethocaine is needed to reach a similar response. The peak effects occurred within 10 to 20 minutes after the injection and decreased to baseline levels within an hour.<ref name="Wilcox_2005" />


Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered [[Intravenous therapy|intravenously]] or nasally, because ingestion would lead to rapid [[Hydrolysis|hydrolyzation]].<ref name="Lindauer_2014" /> It’s positive effects are euphoria, stimulation, increased talkativeness and mood lift.<ref name="TDC" /> However, because the drug acts similar as cocaine, it has comparable negative side effects. These side effects include: [[tachycardia]], difficulty with breathing, pain on the chest, [[vasoconstriction]], [[insomnia]], [[paranoia]] and anxiety.<ref name="TDC" /> Dimethocaine probably poses larger health issues than cocaine. This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.
Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered [[Intravenous therapy|intravenously]] or nasally, because ingestion would lead to rapid [[Hydrolysis|hydrolyzation]].<ref name="Lindauer_2014" /> Its positive effects are euphoria, stimulation, increased talkativeness and mood lift.<ref name="TDC" /> However, because the drug acts similar as cocaine, it has comparable negative side effects. These side effects include: [[tachycardia]], difficulty with breathing, pain on the chest, [[vasoconstriction]], [[insomnia]], [[paranoia]] and anxiety.<ref name="TDC" /> Dimethocaine probably poses larger health issues than cocaine. This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.

There are user reports that confirm unpleasant effects on the heart.<ref>{{Cite news|url=https://drugs-forum.com/threads/iv-dimethocaine-mephedrone.111171/|title=Injecting - - IV Dimethocaine & Mephedrone|work=Drugs-Forum|access-date=2018-03-16|language=en-US}}</ref>


== Toxicity ==
== Toxicity ==


=== Humans ===
=== Humans ===
Cocaine and other local anesthetics are known to produce cardiotoxicity by blocking sodium channels.However, no reports have been published of these same effects of cardiotoxicity associated with dimethocaine.<ref name="Dargan_2013" /> There has been little research about toxicity of dimethocaine in humans, and therefore the exact lethal or pharmacological doses are unknown.
Cocaine and other local anesthetics are known to produce cardiotoxicity by blocking sodium channels. However, no reports have been published of these same effects of cardiotoxicity associated with dimethocaine.<ref name="Dargan_2013" /> There has been little research about toxicity of dimethocaine in humans, and therefore the exact lethal or pharmacological doses are unknown.


=== Animals ===
=== Animals ===
For mice, the dose at which acute toxicity occurs for intravenous administration is 40&nbsp;mg/kg and for [[subcutaneous injection]] (injection in the layer of skin directly below the [[dermis]] and [[Epidermis (skin)|epidermis]]) this is 380&nbsp;mg/kg.<ref>{{Cite web|url=https://www.labscoop.com/SaveAttachment.aspx?type=msds&fileid=157640&allfilenamestore=ucuyzydj__woxzpxptom.pdf&id=63196|title=Material Safety Data Sheet Dimethocaine|last=TOKYO CHEMICAL INDUSTRY CO., LTD.|first=|date=2012-09-28|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref> The lethal dose of dimethocaine for a mouse is 0.3 g per kilogram body weight.<ref name=":0">{{Cite journal|last=Mayer|first=L.L.|date=1935|title=Larocaine, a new anesthetic|url=https://jamanetwork.com/journals/jamaophthalmology/article-abstract/611767|journal=Arch Ophthalmol|volume=14|pages=408–411|via=}}</ref>
For mice, the dose at which acute toxicity occurs for intravenous administration is 40&nbsp;mg/kg and for [[subcutaneous injection]] (injection in the layer of skin directly below the [[dermis]] and [[Epidermis (skin)|epidermis]]) this is 380&nbsp;mg/kg.<ref>{{Cite web|url=https://www.labscoop.com/SaveAttachment.aspx?type=msds&fileid=157640&allfilenamestore=ucuyzydj__woxzpxptom.pdf&id=63196|title=Material Safety Data Sheet Dimethocaine|last=TOKYO CHEMICAL INDUSTRY CO., LTD.|date=2012-09-28}}</ref> The lethal dose of dimethocaine for a mouse is 0.3 g per kilogram body weight.<ref name=":0">{{Cite journal| vauthors = Mayer LL |date=1935|title=Larocaine, a new anesthetic|url=https://jamanetwork.com/journals/jamaophthalmology/article-abstract/611767|journal=Arch Ophthalmol|volume=14|issue=3|pages=408–411|doi=10.1001/archopht.1935.00840090094004}}</ref>


An abdominal constriction test was performed in mice, using doses of 5, 10, and 20&nbsp;mg/kg of dimethocaine which were administered subcutaneously. This test showed induced dose-dependent antinociceptive responses, which are processes that block detection of a painful or injurious stimulus by sensory neurons.<ref name="Rigon_1996" />
An abdominal constriction test was performed in mice, using doses of 5, 10, and 20&nbsp;mg/kg of dimethocaine which were administered subcutaneously. This test showed induced dose-dependent antinociceptive responses, which are processes that block detection of a painful or injurious stimulus by sensory neurons.<ref name="Rigon_1996" />


Impairment of memory processes was found to be a toxic effect in the [[Elevated plus maze|elevated plus-maze]] test in mice.<ref name="Blatt_1998" />
Impairment of memory processes was found to be a toxic effect in the [[Elevated plus maze|elevated plus-maze]] test in mice.<ref name="Blatt_1998" />

== Legal status ==

Sweden's public health agency suggested classifying Dimethocaine as a hazardous substance, on September 25, 2019.<ref>{{cite web | url=https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/september/tretton-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ | title=Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara | publisher=Folkhälsomyndigheten | language=sv | date=25 September 2019 | access-date=11 November 2019 | archive-date=31 October 2019 | archive-url=https://web.archive.org/web/20191031144424/https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/september/tretton-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/ | url-status=dead }}</ref>


== See also ==
== See also ==
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[[Category:Stimulants]]
[[Category:Stimulants]]
[[Category:Local anesthetics]]
[[Category:Local anesthetics]]
[[Category:Benzoates]]
[[Category:4-Aminobenzoate esters]]
[[Category:Anilines]]
[[Category:Anilines]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:Diethylamino compounds]]

Latest revision as of 22:09, 1 February 2024

Not to be confused with Dimethicone.
Dimethocaine
Clinical data
Other namesDMC, larocaine
ATC code
  • none
Legal status
Legal status
Identifiers
  • (3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H26N2O2
Molar mass278.396 g·mol−1
3D model (JSmol)
Density1.0±0.1 g/cm3 (predicted)
Melting point48 to 51 °C (118 to 124 °F) (experimental)
Boiling point334 to 403 °C (633 to 757 °F) at 760 mmHg
  • NC1=CC=C(C(OCC(C)(C)CN(CC)CC)=O)C=C1
  • InChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3 ☒N
  • Key:OWQIUQKMMPDHQQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”.[1] The structure of dimethocaine, being a 4-aminobenzoic acid ester, resembles that of procaine. It is found as a white powder at room temperature.[2]

When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to be a mixture of caffeine and lidocaine,[3] and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded "bath salt" product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.[4]

History

[edit]

Dimethocaine was originally synthesized by the Hoffmann-La Roche company in 1930. It was sold under the market name larocaine. During the 1930s dimethocaine gained popularity in the US as a local anesthetic. Just like cocaine and procaine, it was used during surgery, primarily in dentistry, ophthalmology and otolaryngology. However, in the 1940s, it was removed from the market because of its psychoactive effects and risk of addiction. Nowadays dimethocaine is abused for these psychoactive effects. It is sold as a cocaine surrogate to circumvent legislation issues.[1][5][6]

Pharmacology

[edit]

Pharmacodynamics

[edit]

Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of dopamine (DA) by blocking dopamine transporters (DAT).[7] The dopamine transporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter controls many functions including movement, cognition and mood. Drugs such as cocaine and dimethocaine induce dopamine overflow by inhibiting dopamine transporters and thus creating a euphoric effect.[8] In addition to inhibiting dopamine uptake, dimethocaine was also shown to inhibit the binding of CFT, a different dopamine uptake inhibitor.[7] These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the central nervous system.[5] Both in vivo and in vitro measurements of dopamine transporter activity showed that dimethocaine is a potent and efficacious dopaminergic reuptake inhibitor (also called a dopamine indirect agonist).[7] These effects were mainly observed in the nucleus accumbens, a region in the basal forebrain.[5] Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:[5]

cocaine > dimethocaine > tetracaine > procaine > chloroprocaine

Furthermore, the administration of dimethocaine has been shown to lead to antinociceptive responses at nontoxic doses in mice.[9] These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system. A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.[10]

Pharmacokinetics

[edit]

When inhaled, dimethocaine starts working in 10–30 minutes, with highest effects at 60–120 minutes and until 4–6 hours there is a period of action with the ‘after-effects’.[11] The after effects include fatigue and slight mental impairment.[6]

Metabolism

[edit]

The exact metabolic pathways of dimethocaine have not been researched, but the different metabolites have been examined in Wistar rats. After administration of dimethocaine, different metabolites have been found and identified in their urine. Due to these metabolites, different metabolic pathways could have been postulated. The main phase I reactions are ester hydrolysis, deethylation, hydroxylation of the aromatic system, or a combination of these three.[1] The main phase II reactions are N-acetylation, glucuronidation and a combination of both.[5][1] Different cytochrome P450 isozymes are involved in the initial steps of human metabolism. The N-acetylation is catalyzed by the NAT2 isozyme.[12]

Efficacy and side effects

[edit]

Just like cocaine, dimethocaine inhibits the uptake of dopamine in the brain by interfering with the dopamine transporters.[13] The potency of these drugs is linked to their affinity for the dopamine transporters, and their potency to inhibit dopamine uptake.[7]

In studies with rhesus monkeys the affinity of dimethocaine for dopamine transporters is smaller than that of cocaine, whereas dimethocaine's potency to inhibit dopamine uptake is similar. This means that more of dimethocaine is needed to reach a similar response. The peak effects occurred within 10 to 20 minutes after the injection and decreased to baseline levels within an hour.[13]

Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation.[5] Its positive effects are euphoria, stimulation, increased talkativeness and mood lift.[6] However, because the drug acts similar as cocaine, it has comparable negative side effects. These side effects include: tachycardia, difficulty with breathing, pain on the chest, vasoconstriction, insomnia, paranoia and anxiety.[6] Dimethocaine probably poses larger health issues than cocaine. This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.

Toxicity

[edit]

Humans

[edit]

Cocaine and other local anesthetics are known to produce cardiotoxicity by blocking sodium channels. However, no reports have been published of these same effects of cardiotoxicity associated with dimethocaine.[2] There has been little research about toxicity of dimethocaine in humans, and therefore the exact lethal or pharmacological doses are unknown.

Animals

[edit]

For mice, the dose at which acute toxicity occurs for intravenous administration is 40 mg/kg and for subcutaneous injection (injection in the layer of skin directly below the dermis and epidermis) this is 380 mg/kg.[14] The lethal dose of dimethocaine for a mouse is 0.3 g per kilogram body weight.[15]

An abdominal constriction test was performed in mice, using doses of 5, 10, and 20 mg/kg of dimethocaine which were administered subcutaneously. This test showed induced dose-dependent antinociceptive responses, which are processes that block detection of a painful or injurious stimulus by sensory neurons.[9]

Impairment of memory processes was found to be a toxic effect in the elevated plus-maze test in mice.[10]

[edit]

Sweden's public health agency suggested classifying Dimethocaine as a hazardous substance, on September 25, 2019.[16]

See also

[edit]

References

[edit]
  1. ^ a b c d Meyer MR, Lindauer C, Welter J, Maurer HH (March 2014). "Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its detectability in urine by means of a rat model and liquid chromatography-linear ion-trap (high-resolution) mass spectrometry". Analytical and Bioanalytical Chemistry. 406 (7): 1845–54. doi:10.1007/s00216-013-7539-0. PMID 24448968. S2CID 10850370.
  2. ^ a b Dargan P, Wood D (2013-08-06). Novel Psychoactive Substances: Classification, Pharmacology and Toxicology. Amsterdam: Elsevier/Academic Press. ISBN 978-0-12-415911-2.
  3. ^ Brandt SD, Sumnall HR, Measham F, Cole J (July 2010). "Second generation mephedrone. The confusing case of NRG-1". BMJ. 341: c3564. doi:10.1136/bmj.c3564. PMID 20605894. S2CID 20354123.
  4. ^ An overview of new psychoactive substances and the outlets supplying them Archived November 25, 2011, at the Wayback Machine
  5. ^ a b c d e f Lindauer C (2014). Toxicokinetics of Emerging Drugs of Abuse: In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine. Homburg/Saar: University of Saarland.
  6. ^ a b c d "Dimethocaine - The Drug Classroom". The Drug Classroom. Retrieved 2018-03-16.
  7. ^ a b c d Woodward JJ, Compton DM, Balster RL, Martin BR (April 1995). "In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter". European Journal of Pharmacology. 277 (1): 7–13. doi:10.1016/0014-2999(95)00042-J. PMID 7635175.
  8. ^ Vaughan RA, Foster JD (September 2013). "Mechanisms of dopamine transporter regulation in normal and disease states". Trends in Pharmacological Sciences. 34 (9): 489–96. doi:10.1016/j.tips.2013.07.005. PMC 3831354. PMID 23968642.
  9. ^ a b Rigon AR, Takahashi RN (June 1996). "The effects of systemic procaine, lidocaine and dimethocaine on nociception in mice". General Pharmacology. 27 (4): 647–50. doi:10.1016/0306-3623(95)02079-9. PMID 8853299.
  10. ^ a b Blatt SL, Takahashi RN (April 1998). "Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice" (PDF). Brazilian Journal of Medical and Biological Research. 31 (4): 555–9. doi:10.1590/s0100-879x1998000400013. PMID 9698809.
  11. ^ Greene SL (2013). "Miscellaneous Compounds". Novel Psychoactive Substances. pp. 393–409. doi:10.1016/b978-0-12-415816-0.00017-1. ISBN 9780124158160.
  12. ^ Meyer MR, Lindauer C, Maurer HH (February 2014). "Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2". Toxicology Letters. 225 (1): 139–46. doi:10.1016/j.toxlet.2013.11.033. PMID 24309420.
  13. ^ a b Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL (December 2005). "In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys". Synapse. 58 (4): 220–8. CiteSeerX 10.1.1.327.1264. doi:10.1002/syn.20199. PMID 16206183. S2CID 15631376.
  14. ^ TOKYO CHEMICAL INDUSTRY CO., LTD. (2012-09-28). "Material Safety Data Sheet Dimethocaine".
  15. ^ Mayer LL (1935). "Larocaine, a new anesthetic". Arch Ophthalmol. 14 (3): 408–411. doi:10.1001/archopht.1935.00840090094004.
  16. ^ "Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 25 September 2019. Archived from the original on 31 October 2019. Retrieved 11 November 2019.
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