3-Јodotironamin – razlika između verzija

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| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2
| StdInChI = 1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| Beilstein =
| Gmelin =
| 3DMet =
| StdInChIKey = XIINYOJWNGOUPF-UHFFFAOYSA-N
| StdInChIKey = XIINYOJWNGOUPF-UHFFFAOYSA-N
| CASNo = 712349-95-6
| CASNo = 712349-95-6
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}}
}}


'''3-Jodotironamin''' (T<sub>1</sub>AM) je [[endogen]]i [[tironamin]]. T<sub>1</sub>AM je [[ligand]] visokog afiniteta za [[trag amin-asocirani receptor]] [[TAAR1]] (TAR1, TA1), nedavno otkriveni [[G protein spregnuti receptor]].<ref>{{cite journal |author=Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D |title=3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone |journal=Nat. Med. |volume=10 |issue=6 |pages=638–42 |year=2004 |pmid=15146179 |doi=10.1038/nm1051}}</ref><ref>{{cite journal |author=Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T |title=Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues |journal=J. Med. Chem. |volume=49 |issue=3 |pages=1101–12 |year=2006 |pmid=16451074 |doi=10.1021/jm0505718}}</ref> T<small><sub>1</sub></small>AM je najpotentniji TAAR1 agonist do sada otkriven.<ref name="Wu">{{Cite journal
'''3-Jodotironamin''' (T<sub>1</sub>AM) je [[endogen]]i [[tironamin]]. T<sub>1</sub>AM je [[ligand]] visokog afiniteta za [[trag amin-asocirani receptor]] [[TAAR1]] (TAR1, TA1), nedavno otkriveni [[G protein spregnuti receptor]].<ref>{{cite journal |author=Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D |title=3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone |journal=Nat. Med. |volume=10 |issue=6 |pages=638–42 |year=2004 |pmid=15146179 |doi=10.1038/nm1051}}</ref><ref>{{cite journal |author=Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T |title=Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues |journal=J. Med. Chem. |volume=49 |issue=3 |pages=1101–12 |year=2006 |pmid=16451074 |doi=10.1021/jm0505718}}</ref> T<sub>1</sub>AM je najpotentniji TAAR1 agonist do sada otkriven.<ref name="Wu">{{Cite journal
| author = Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ
| author = Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ
| doi = 10.1089/thy.2005.15.943
| doi = 10.1089/thy.2005.15.943
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| year = 2005
| year = 2005
| pmid = 16131336
| pmid = 16131336
}}</ref> Aktivacija TAAR1 receptora T<small><sub>1</sub></small>AM ligandom dovodi do produkcije velikih količina cAMP-a. Taj efekat je spregnut sa sniženjem telesne temperature i srčanog izlaza.<ref>{{cite web |url=http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php |title=New compound may act to keep thyroid activity in check |format= |work= |accessdate = 30. 5. 2008.}}</ref> T<sub>1</sub>AM je deo signalnog puta koji moduliše srčanu funkciju.<ref>{{cite journal |author=Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. |title=Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function |journal= The FASEB journal : official publication of the Federation of American Societies for Experimental Biology|volume= 21|issue= 7|pages= 1597–608|year=2007 |pmid=17284482 |doi=10.1096/fj.06-7474com}}</ref>
}}</ref> Aktivacija TAAR1 receptora T<sub>1</sub>AM ligandom dovodi do produkcije velikih količina cAMP-a. Taj efekat je spregnut sa sniženjem telesne temperature i srčanog izlaza.<ref>{{cite web |url=http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php |title=New compound may act to keep thyroid activity in check |format= |work= |accessdate = 30. 5. 2008.}}</ref> T<sub>1</sub>AM je deo signalnog puta koji moduliše srčanu funkciju.<ref>{{cite journal |author=Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. |title=Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function |journal= The FASEB journal : official publication of the Federation of American Societies for Experimental Biology|volume= 21|issue= 7|pages= 1597–608|year=2007 |pmid=17284482 |doi=10.1096/fj.06-7474com}}</ref>


== Reference ==
== Reference ==
{{Reflist}}
{{Reflist}}


==Vidi još==
== Povezano ==
* [[Trag amini]]
* [[Trag amini]]
* [[O-fenil-3-jodotiramin]]
* [[O-fenil-3-jodotiramin]]


==Spoljašnje veze==
== Spoljašnje veze ==
{{Portal-lat|Hemija}}
{{Portal-lat|Hemija}}
* {{MeshName|3-iodothyronamine}}
* {{MeshName|3-iodothyronamine}}
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[[Kategorija:Jodirani derivati tirozina]]
[[Kategorija:Jodirani derivati tirozina]]
[[Kategorija:Fenolni etri]]
[[Kategorija:Fenolni etri]]
[[Kategorija:Fenetilamini]]
[[Категорија:Фенетиламини]]

Aktualna verzija na datum 18 august 2024 u 00:41

3-Јodotironamin
IUPAC ime
Drugi nazivi T1AM
Identifikacija
CAS registarski broj 712349-95-6
ChemSpider[1] 8126125 DaY
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C14H14INO2
Molarna masa 355,17 g/mol

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

3-Jodotironamin (T1AM) je endogeni tironamin. T1AM je ligand visokog afiniteta za trag amin-asocirani receptor TAAR1 (TAR1, TA1), nedavno otkriveni G protein spregnuti receptor.[2][3] T1AM je najpotentniji TAAR1 agonist do sada otkriven.[4] Aktivacija TAAR1 receptora T1AM ligandom dovodi do produkcije velikih količina cAMP-a. Taj efekat je spregnut sa sniženjem telesne temperature i srčanog izlaza.[5] T1AM je deo signalnog puta koji moduliše srčanu funkciju.[6]

Reference

[uredi | uredi kod]
  1. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  2. ↑ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). „3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone”. Nat. Med. 10 (6): 638–42. DOI:10.1038/nm1051. PMID 15146179. 
  3. ↑ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). „Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues”. J. Med. Chem. 49 (3): 1101–12. DOI:10.1021/jm0505718. PMID 16451074. 
  4. ↑ Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ (2005). „Alternate Pathways of Thyroid Hormone Metabolism”. Thyroid 15 (8): 943–958. DOI:10.1089/thy.2005.15.943. PMID 16131336. 
  5. ↑ „New compound may act to keep thyroid activity in check”. Pristupljeno 30. 5. 2008. 
  6. ↑ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). „Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function”. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 (7): 1597–608. DOI:10.1096/fj.06-7474com. PMID 17284482. 

Povezano

[uredi | uredi kod]

Spoljašnje veze

[uredi | uredi kod]
Portal Hemija
Izvor: https://sh.wikipedia.org/w/index.php?title=3-Јodotironamin&oldid=42169435