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GRLF1

From Wikipedia, the free encyclopedia
ARHGAP35
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35
External IDsOMIM: 605277; MGI: 1929494; HomoloGene: 35136; GeneCards: ARHGAP35; OMA:ARHGAP35 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004491
NM_024342

NM_172739

RefSeq (protein)

NP_004482

NP_766327

Location (UCSC)Chr 19: 46.86 – 47.01 MbChr 7: 16.23 – 16.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.[5][6]

Function

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The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160007Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058230Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Sep 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". The Journal of Biological Chemistry. 266 (26): 17333–40. doi:10.1016/S0021-9258(19)47378-X. PMID 1894621.
  6. ^ a b "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.