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KCNIP1

From Wikipedia, the free encyclopedia
KCNIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDsOMIM: 604660; MGI: 1917607; HomoloGene: 22824; GeneCards: KCNIP1; OMA:KCNIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001034837
NM_001034838
NM_001278339
NM_001278340
NM_014592

NM_001190885
NM_001190886
NM_001290690
NM_027398
NM_001363115

RefSeq (protein)

NP_001030009
NP_001030010
NP_001265268
NP_001265269
NP_055407

NP_001177814
NP_001177815
NP_001277619
NP_081674
NP_001350044

Location (UCSC)Chr 5: 170.35 – 170.74 MbChr 11: 33.58 – 33.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[5][6]

Function

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This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182132Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053519Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964. S2CID 4419472.
  6. ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
  7. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.